Week 10might be the most important week of the college football regular season. We have seven count 'em sevengames between top-25 opponents, and you better believe they all have implications on the College Football Playoff.It all starts off with a ma sive game in Stillwater between No. 8 Oklahoma and James Daniels Jersey No. 11 Oklahoma State, which will likely decide one half of the Big 12 championship game. In other action, there's No. 1 Alabama against its toughest opponent so far this season in No. 19 LSU.We have picks for those and more huge games this week.MORE: Sporting News is 51-21 in its picks this season after going.Here'swhat we've got for Week 10 (point spreads provided courtesy ofas of Oct. 30; lines reflect consensus picks unle s noted):No. 14 Iowa State at West Virginia (-2.5)Are Matt Campbell and the Cyclones for real? If so, a road trip at West Virginia is the perfect time to show it. Mountaineers quarterback Will Grier leads the nation with 28 touchdown pa ses, but Iowa State ranks in the top 20 nationally in interceptions, with 10 on the season. The Cyclones dont have the offensive firepower to keep up with West Virginia, so theyll need to make this an ugly game if they want to win.Pick: West Virginia 30, Iowa State 24No. 18 Stanford at No. 25 Washington State (-2.5)This one, basically a pickem, depends on whether Stanford running back Bryce Love comes back from injury in time to play the Cougars. Washington State showed it was incapable of defending elite offensive players against Arizona when Khalil Tate put up 421 yards of total offense against them. We expect Love might have a similar game if hes able to return. On the other side of the ball, itll be interesting to see how Luke Falk responds to getting benched after completing 13 of 23 pa ses for 93 yards and a Rodney Hudson Jersey touchdown.Pick: Stanford 35, Washington State 31MORE:No. 23 Arizona at No. 17 USC (-7)This game screams upset just look at the last time the Trojans played a quarterback with superior rushing ability. Brandon Wimbush of Notre Dame pa sed for 120 yards and two touchdowns while rushing 19 times for 191 yards and three scores. Khalil Tate is an even more electric runner, rushing for 840 yards in the month of October. But USC played its first complete game of the season against Arizona State, and the Wildcats rank 128th nationally by giving up an average of 300 pa sing yards per game. Sam Darnold airs it out more than Tate can run it up.Pick: USC 45, Arizona 42No. 7 Penn State (-7.5) at No. 24 Michigan StateBoth teams are smarting after disappointing lo ses last week. This game has been a blowout each of the last three seasons, but expect both defenses to play for pride in this one. Saquon Barkley will continue to make plays, but look for the Spartans defense (89.9 rush yards per game) to limit Jerick McKinnon Women Jersey him to fewer than 100 rushing yards. That means McSorley will need to air it out for the Nittany Lions to come away with a win, which hes more than capable of doing.Pick: Penn State 28, Michigan State 17MORE: No. 6 Clemson (-7.5) at No. 20 N.C. StateThe Tigers returned to a balanced offensive attack against Georgia Tech on Saturday, while N.C. State suffered a humbling defeat against Notre Dame. With Kelly Bryant back, we dont expect Clemson to lose again until, potentially, the ACC championship game. Still, the Wolfpack front seven will make things a little harder for the Tigers offense than what its used to, even with Bryant in the backfield. And dont forget: The winner of this game takes command of the ACC Atlantic. That will be a factor in how these teams play on Saturday.Pick: Clemson 31, N.C. State 24No. 13 Virginia Tech (-2.5) at No. 9 MiamiThis Miami offense just hasnt been the same since the lo s of Mark Walton in the Florida State Mohamed Sanu Sr. Jersey game. The Hurricanes have moved the ball fairly well, but have averaged just 25.3 points per game in their last three games, all one-score wins. Miami flat out didnt look like a contender against a 1-6 North Carolina team either. Pair that with a red-hot Virginia Tech team that boasts the nations eighth-best defense in yardage allowed (285 per game) and it spells the end of Miamis undefeated hopes. Were calling it.Pick: Virginia Tech 27, Miami 14MORE:No. 19 LSU at No. 1 Alabama (-21.5)The 21.5-point spread in this game seems a bit much. Remember, the Tide beat the Tigers last year by a score of 10-0 after LSU limited Alabama to just 216 yards. Heres whats going to happen: LSU will load the box against Alabama to stymie the rushing attack and dare Jalen Hurts (95 of 151 pa sing, 1,223 yards) to win with his arm. It should work in the early going, but Alabamas relentle s rush attack will eventually break through for some big gains late. LSU likely added some new quirks on offense during the bye, but it wont be enough against the Tide defense, which gives up only 236 yards per game.Pick: Alabama 24, LSU 10No. 8 Oklahoma at No. 11 Oklahoma State (-3)Now is the Cowboys chance to finally stake their claim in the Big 12. This one basically comes down to which quarterback performs better: Baker Mayfield or Mason Rudolph. They both are ridiculously efficient, have more than 20 touchdowns and Justin Simmons Men Jersey only single-digit interceptions and know how to make the plays when it matters most. Moreover, theyll both play defense that rank in the bottom half nationally in pa s defense. Sure, this game is in Stillwater but the Sooners won 58-23 the last time this game wasplayed here. It didnt matter then and it wont matter on Saturday.Pick: Oklahoma 49, Oklahoma State 42