QuickBooks error 15106 generally occurs while updating the QuickBooks Desktop to the latest release. When this error occurs, you will get a message "Error 15106: The update program cannot open".
Steps to fix QuickBooks Error 15106
Log in as an Administrator on Your Computer
Click on Start.
Go to the Control Panel.
Click on User Accounts.
Select Change Account Type.
Then choose the Administrator option if it is standard.
If you still face the error you can call our technical experts at QuickBooks Phone Number +1-520-463-7633.