If you're experiencing issues with Outlook, starting it in Safe Mode can help you troubleshoot the problem. To do this, hold down the "CTRL" key and click on the Outlook icon. You'll see a prompt asking if you want to start Outlook in Safe Mode. Click "Yes" and Outlook will start with all add-ins disabled. From there, you can try disabling problematic add-ins or repairing your Outlook data files. Starting Outlook in Safe Mode can help you identify and resolve issues that may be affecting its performance.